The storyline of Quarantine is set in a place which is known as the Kemo town. In the town, the sky has a tint of gray and the buildings have been shattered. The player, being an unemployed person, is finding difficult to survive the poverty. When the player loses hope and thinks that this is the dead end and things cannot get worse as compared to the present situation, suddenly, all breaks fail. Cars start rushing through the streets aimlessly and in order to save himself from those speeding cars, the player finds shelter in the closest building he finds.
The story of Quarantine continues as life kicks the player badly. The cars are loaded with weapons and several bullets are being fired. Some of the bullets find their way in the place where you are sheltering in. People are scared and are shouting as the town is being painted with red color. Somehow, the player manages to escape that building, keeping in mind the possible dangers he could face inside it and reaches to a dark pathway. The pathway is surrounded by huge walls and therefore, the bullets cannot penetrate through these walls. So, the player rests and comes up with a strategy.
Soon, the player finds out that the cars are not shooting the people of the city; instead, they are aiming at each other. As the cars contain weapons, the player thinks that it would be safer inside the car and, he could even offer whatever he as to the car driver for driving him home. The player wanted to rush to his home as he wanted to use the new rifle that he bought a couple of days earlier.
The game is filled with action, thrill, and fun.